The two European heavyweights will face-off in the United States as they prepare for the start of their respective league campaigns.
Tonight’s game is part of the International Champions Cup.
Manchester United and Real Madrid have both won the trophy since its arrival four-years ago.
Arsenal, Bayern Munich, Manchester City and PSG are also taking part in the competition.
United’s new hotshot striker Romelu Lukaku has already played a part in the Red Devils’ US pre-season and scored for them.
However, one forward who will not be playing any part in the game is Cristiano Ronaldo.
The Portugese wing wizard, who made a name for himself at United before moving to Madrid, has not gone with Zinedine Zidane's squad to the US.
However, Madrid Galacticos such as Gareth Bale and Karim Benzema could face off against Manchester United tonight.
How To Watch Manchester United v Real Madrid
Coverage of Manchester United vs Real Madrid in the International Champions Cup will be shown live on MUTV and MUTV HD.The pre-match build-up starts at midnight and kick-off is set for 2pm local time, which works out at 9pm BST.
The Manchester derby will also be shown on the MUTV website, and it costs £4.99 per month to subscribe.
