Jose Mourinho and Pep Guardiola face off in Houston as the two Manchester clubs go head-to-head.
United and City were well off the pace last season but cannot afford to not be challenging this time around.
The Red Devils have already splashed the cash on Romelu Lukaku and Victor Lindelof, while City have also been busy.
Guardiola has brought in Ederson, Kyle Walker and Bernardo Silva and more new faces are expected.
The clash in Houston is City's first in pre-season while United have picked up wins over LA Galaxy and Real Salt Lake.
Can Mourinho's men make it three wins out of three?
Man United XI: De Gea; Valencia, Lindelof, Smalling, Blind; Herrera, Pogba; Mkhitaryan, Lingard; Rashford, Lukaku
Man City XI: Ederson, Adarabioyo, Kompany, Fernandinho; Walker, Toure, Foden, De Bruyne, Roberts, Sterling; Aguero
